#1 – Heist #1

First mission leading to a heist on Caligula's Palace becomes available after completing the main story mission Explosive Situation. The last mission (the heist) will be available after completing all previous missions from the series, the main story mission Saint Mark's Bistro and obtaining keycard from Millie Perkins. You will meet and start dating Millie during second mission. There are two ways to obtain keycard, first is to date her until reaching 35% progress with her. Second, the easier one, is to kill her - but you won't be able to date her again, even after collecting all the oysters. Completing the heist is required to complete the game at 100% and it is rewarded with 100.000 GTA$.